Guide: Mixing Antidepressants with Marijuana

The mix of antidepressants and marijuana can lead to complications such as tachycardia, panic attacks, and even hallucinations. Are these risks something that you are aware of?

In the United States, about 11% of Americans that are the age of 12 and over now take an antidepressant of some sort. Additionally, more than 22 million people have reportedly used marijuana during the last month. Studies forsee marijuana use being on the rise as more states begin to legalize the drug.

Unfortunately, many people don’t understand how the two drugs interact. Nor do they understand the associated risks of combining them. Don’t worry, we’ve compiled a thorough guide to mixing antidepressants and marijuana.

Here’s everything you need to know. Let’s start by considering the nature of both, and why they’re often used together.

Mixing Antidepressants & Marijuana

Antidepressants balance the brain chemicals (neurotransmitters) that affect your emotions. Their use can help to improve your mood, sleep, appetite, and concentration.

Alone, antidepressants aren’t as addictive as other substances, such as alcohol or opioids. But users can still develop a physical dependence on them. In fact, the idea that prescription medications can’t cause problems is one of the biggest myths of addiction.

Antidepressants help many people to cope with their symptoms. Marijuana is another substance that has the potential to cause abuse problems, but can also be beneficial in some instances. In fact, many find that marijuana helps them feel less stressed.Mixing Antidepressants with Marijuana

Depression itself is often associated with increased life stressors. So it’s no surprise that people taking antidepressants are 8x more likely to also use cannabis.

As so many mix antidepressants with marijuana, it may be assumed that there is little harm in this practice. Unfortunately, that’s not the case…

Mixing Marijuana with Antidepressants Research

There is surprisingly little research that has examined how marijuana and antidepressants interact.

Smoking Marijuana while taking AntidepressantsIt’s hard to know exactly why this is, but it could be down to a low awareness of potential side effects. It could also be due to the reluctance of those taking antidepressants to disclose that they are also taking marijuana.

Perhaps it’s down to the range of antidepressants. There are several different forms, and each interacts with marijuana differently.

Here we’ll consider each in turn. Let’s start with SSRIs.

SSRIs & Marijuana

Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed type of antidepressant. Examples of SSRIs include:SSRIS & MARIJUANA

  • Citalopram (Cipramil)
  • Fluoxetine (Prozac)
  • Fluvoxamine (Luvox)
  • Sertraline (Zoloft)
  • Paroxetine (Aropax)

Typically SSRIs are associated with low rate of side effects. Yet, there are anecdotal reports of users experiencing severe panic attacks after mixing them with marijuana.

SNRIs & Marijuana

Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a newer class of anti-depressants. Examples of SNRIs include:

  • Desvenlafaxine (Pristiq)
  • Duloxetine (Cymbalta)
  • Levomilnacipran (Fetzima)
  • Venlafaxine (Effexor)

Serotonin-norepinephrine reuptake inhibitorsAs a newer type of anti-depressants, SNRIs perhaps have the lowest chance of adverse effects when mixed with marijuana. These medications have a higher ‘therapeutic index’. That means they offer a reduced chance of adverse interaction.

Still, as these antidepressants are much newer, there is much less published research to evaluate them. It’s not advised to mix marijuana with SNRIs, due to this uncertainty.

TCAs & Marijuana

Tricyclic antidepressants (TCAs) are another form of antidepressant. Examples of TCAs include:Tricyclic antidepressants

  • Amitriptyline (Tryptanol)
  • Imipramine (Tofranil)
  • Dosulepin (Prothiaden)
  • Nortriptyline (Allegron)
  • Clomipramine (Anafranil)

Marijuana has been shown to interact negatively with tricyclic antidepressants. In fact, several case studies have shown that mixing both can result in delirium and tachycardia (an abnormally fast heartbeat).

Other noted side effects include:

  • high blood pressure
  • mood swings
  • hallucinations

Because of this, it’s strongly advised that you do not take marijuana if currently using TCA antidepressants.

MAOIs & Marijuana

Monoamine oxidase inhibitors (MAOIs) are the original antidepressants. Nowadays, they are prescribed quite infrequently. Examples of MAOIs include:

  • Phenelzine (Nardil)
  • Tranylcypromine (Parnate)
  • Moclobemide (Aurorix)

Monoamine oxidase inhibitorsThere is no direct evidence to link the use of MAOIs and marijuana to adverse effects. However, MAOIs are well known for their tendency to induce negative side effects, and this is why they are now used rarely.

As such, MAOI users are discouraged from also taking marijuana.

Sedatives & Marijuana

Sedatives are not actually antidepressants. But, as they are commonly prescribed to those experiencing depression, it’s relevant to mention them here.

Examples of sedatives include:Mixing Sedatives and Marijuana

  • Lonazepam (Klonopin)
  • Lorazepam (Ativan)
  • Phenobarbital (Donnatal)
  • Zolpidem (Ambien)

Both marijuana and sedatives are known to cause drowsiness. As such, mixing both is likely to amplify the effect. This can have implications for day-to-day safety, including driving and operating machinery.

Absorption & Adherence of Mixing Marijuana with Antidepressants

Even in cases where antidepressants appear to be low risk, there are other factors to consider.

For example, the use of marijuana can affect absorption rates. This means marijuana has the potential to make antidepressants less effective. It is also possible that those using marijuana are less likely to adhere to the prescribed antidepressant dosage, because of this.

For patients experiencing significant depression, the potential impact could be life-threatening.


Mixing antidepressants and marijuana also make it hard for a doctor to give accurate dosage prescriptions. For users, it can also be difficult to understand the true impact of antidepressants, when used alongside marijuana.

If you wish to begin taking antidepressants you should, at the least, temporarily abstain from taking marijuana. If you’re able to first determine a sufficient dosage of antidepressants, you’re less likely to meet complications.

Individual Differences

As with all medications, individual (genetic) differences can play a big role. Mixing antidepressants and marijuana might be relatively safe for some, but disastrous for others.

The best option is to talk to your doctor about mixing antidepressants and marijuana. That way adverse health effects can be mitigated wherever possible.

If you’re taking antidepressants, it’s very important that your doctor is aware of your cannabis use.

Getting Help

Used alone, antidepressants and marijuana both carry their own risks. But when combined, you face the potential of added health complications.

This is particularly risky for users mixing marijuana with higher risk antidepressant types, such as TCAs and MAOIs.

Is someone you know struggling with drug addiction?

If so, and you’re searching for a way to help, consider our drug & alcohol detox program, which can help users limit withdrawal symptoms.


Related Posts


Essential Professional and Relationship Life Skills While in Drug Rehab

Recovery from alcoholism or addiction takes much more than staying abstinent from your preferred substance. Many people use drugs and drink because they have a hard time living properly.  The…

How a Residential Treatment Program Works for Drug or Alcohol Addiction

A residential treatment program is the number one way for someone to start there life journey in recovery from drug addiction. Often those with addiction attempt to go to outpatient…